Introduction | The System of MAnorm2 Machinery | Input Data | Application Scope | Continuous Distribution | MAnorm2 Capability | Comparing Groups of ChIP-seq Samples | Quick Start | Step-by-step Explanation and Visualization | Normalization | Modeling Mean-Variance Trend | Differential Tests | When No Replicates Are Available | Simultaneous Comparison of Any Number of Groups | Combining Replicates and Using Local Regression | Identifying Hypervariable ChIP-seq Signals | Clustering ChIP-seq Samples | MAnorm2 Model Formulation | Citation | Acknowledgments | Session Info | References