Changes in version 1.2.2 (2022-10-28) o Allow p_low and p_up to be larger than 0.5 in the Winsorization framework, as long as their sum is strictly smaller than 1. Changes in version 1.2.1 (2022-08-30) o Update the citation of HyperChIP. o Fix some math rendering problems in HTML manuals. Changes in version 1.2.0 (2021-09-13) o Add the citation of HyperChIP. o Uploaded to the CRAN repository. Changes in version 1.1.0 o Add an option of using a pseudo-reference profile as baseline when performing normalization. o Implement a robust parameter estimation method that is based on Winsorization. o Implement the HyperChIP method for hypervariable ChIP-seq analysis. Changes in version 1.0.0 o The first release of MAnorm2. o Uploaded to GitHub.